MyBioSource.com's H-NUC Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The H-NUC Antibody was generated using APC3, CDC27, and HNUC as the antigen and it reacts with Human, Mouse, and Rat.
Description
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.Tugendreich S., Proc. Natl. Acad. Sci. U.S.A. 90:10031-10035(1993).Chen P.L., Cell Growth Differ. 6:199-210(1995).Kraft C., EMBO J. 22:6598-6609(2003)